Shit on (shingles)
Biscuits and Gravy
Most medications should be stored at room temperature (59°F to 77°F). While many medications require refrigeration (36°F to 46°F), freezing is dangerous for most drugs as it destroys their chemical structure or physical stability.
Baystate Health
+2
However, a select few specific medications actively require frozen storage (usually between -13°F and 5°F).
Medications That Require a Freezer
Most of these are highly sensitive biologicals, vaccines, or specific suppositories:
Vaccines: Varicella (chickenpox) and Zoster (shingles) vaccines.
Hormonal Inserts: Dinoprostone vaginal inserts (Cervidil) and suppositories (Prostin E2).
Specialized Medications: Anthrax immune globulin (Anthrasil) and Carmustine wafers (Gliadel).
IEHP
+1
Medications That MUST Be Refrigerated (But NOT Frozen)
Many medications need to be kept cold, but will be ruined if they freeze. Examples include:
GoodRx
+2
Insulin: All forms.
GLP-1s & Biologics: Ozempic, Humira, Enbrel, and Copaxone.
Eye Drops: Many prescription drops, especially for glaucoma (e.g., Latanoprost).
Liquid Antibiotics: Such as Amoxicillin (once mixed by the pharmacy).
Other Injectables: Fertility medications (Gonal-f, Follistim) and growth hormones.
GoodRx
+4
What if your medicine froze?
If any medication that is not meant to be frozen experiences a solid freeze, it is generally no longer safe or effective to use. Some suspensions separate, and proteins in biologics can break down.
Baystate Health
+3
Because you cannot always see physical changes, use the GoodRx Medication Finder to read up on your specific product, or contact a local pharmacist to see if a frozen medication needs to be replaced









